Districts' use of thrombolytic agents.

Districts' use of thrombolytic agents.

The use of thrombolytic agents.

Thrombi and thromboemboli are organized fibrin clots that may result in partial or total occlusion of arterial or venous blood flow. Consequences of occlusion of blood flow vary with the organ affected.Thrombolytic agents have been used for the dissolution of pathologic thrombi since the 1980s. While similar in their mechanisms of action and side effects, these agents differ in their specificit...

History of Thrombolytic Agents

Thrombolytics recanalize thrombotic occlusion associated with STsegment elevation myocardial infarction (STEMI) and restoration of coronary flow reduces infarct size and improves myocardial function and survival over the short-term and long-term. Thrombolytic therapy for acute myocardial infarction (AMI) was incorporated into the armamentarium of clinicians over 2 decades ago, and has evolved f...

Role of thrombolytic agents in cardiac arrest.

The prognosis of patients having a cardiac arrest is generally poor, with a few exceptions. Interventions that aim to improve outcome in cardiac arrest have proved to be disappointing. In particular, no drug has been reliably proved to increase survival to discharge after cardiac arrest. Given that coronary thrombosis in situ and pulmonary thromboembolism are implicated in a large proportion of...

THROMBOLYSIS Synergism of thrombolytic agents in vivo

The existence of significant synergism between tissue-type plasminogen activator (t-PA) and single-chain urokinase-type plasminogen activator (scu-PA), and between t-PA and urokinase in thrombolysis in vivo is described. In a quantitative preparation of thrombolysis, consisting of rabbits in which a blood clot was induced in the jugular vein with `251-labeled fibrin, intravenous infusion over 4...